Key result
Ongoing statin administration the previous evening was associated with a significantly higher odds of being assessed as free of delirium the following day (OR 2.28) in critically ill patients.
Why the study?
Does statin therapy reduce the risk of delirium in critically ill patients?
Cohort (n=470)
No
Does statin therapy reduce the risk of delirium in critically ill patients?
Odds Ratio: 2.28 (95% CI 1.01–5.13)
p-value: p=<0.05
Ongoing statin therapy in critically ill patients is associated with a lower daily risk of delirium, an effect that may be mediated by reduced inflammation.
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Associated with lower daily delirium risk in critically ill patients; hypothesis-generating and requires RCTs before any practice change.
Page et al. (2014) conducted a cohort in Critically ill (ICU admission) (n=470). Statin therapy vs. No statin therapy was evaluated on Assessed as free of delirium the following day (OR 2.28, 95% CI 1.01-5.13, p=<0.05). Ongoing statin administration the previous evening was associated with a significantly higher odds of being assessed as free of delirium the following day (OR 2.28) in critically ill patients.
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