Key result
Prior statin use is linked to ~15% higher delirium prevalence during mechanical ventilation.
Why the study?
Delirium is common and associated with high morbidity and mortality in ICU patients receiving mechanical ventilation, but the impact of statin use on delirium occurrence is unclear.
Does statin use increase the prevalence of delirium in ICU patients undergoing mechanical ventilation?
Cross-Sectional (n=18,146)
No
Does statin use increase the prevalence of delirium in ICU patients undergoing mechanical ventilation?
Odds Ratio: 1.15 (95% CI 1.01–1.37)
Absolute Event Rate: 7.9% vs 7.4%
p-value: p=<0.05
No takes yet. Share an insight, caveat, or question.
Should not yet alter statin use; cross-sectional data leave open causality for delirium in ventilated patients.
Liu et al. (2025) conducted a cross-sectional in Delirium in ICU patients receiving mechanical ventilation (n=18,146). Statin use vs. No statin use was evaluated on Prevalence of delirium (OR 1.15, 95% CI 1.01-1.37, p=<0.05). Statin use prior to ICU admission was associated with a 15% higher prevalence of delirium in patients undergoing mechanical ventilation (OR 1.15).
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