September 1, 2009Archives of Pathology & Laboratory Medicine
Increased Mean Platelet Volume in Patients With Acute Coronary Syndromes
Why the study?
Does mean platelet volume (MPV) measurement improve the diagnosis of acute coronary syndromes in adult patients presenting with chest pain?
Population
2,304 adult patients consecutively admitted during a 1-year period to the emergency department for chest…
Comparison
Mean platelet volume (MPV) measurement vs Non-ACS patients with normal cardiac troponin T…
Design
Cohort
Follow-up
up to 12 hours (for troponin measurements)
Authors
Discussion
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Member takes
Implication
Elevated MPV was associated with ACS; leaves open diagnostic utility and should not yet change practice.
Structured PICO
Does mean platelet volume (MPV) measurement improve the diagnosis of acute coronary syndromes in adult patients presenting with chest pain?
P
Population
2,304 adult patients consecutively admitted during a 1-year period to the emergency department for chest pain suggestive of acute coronary syndromes (ACS)
I
Intervention
Mean platelet volume (MPV) measurement
C
Comparator
Non-ACS patients with normal cardiac troponin T levels
O
Outcome
Diagnosis of ACS (defined as cardiac troponin T levels ≥0.03 ng/mL and ischemic electrocardiographic changes)surrogate
Mean platelet volume is a simple, inexpensive biomarker that is significantly elevated in ACS and may serve as a useful rule-out test in patients presenting with chest pain.
Cite This Study
Lippi et al. (2009) studied this question.