The study demonstrates that sodium delivery to the macula densa and dietary salt intake modulate the activation and total amount of renin in the juxtaglomerular apparatus.
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Does not alter clinical renin or salt management; hypothesis-generating for macula densa sodium effects on renin in humans.
Renin was measured in individual juxtaglomerular apparatuses before and after acidification in vitro. 2. Active renin increased with delivery of extra sodium by microperfusion to the macula densa and this increase was similar to that achieved with acidification. 3. In rats pretreated with an inhibitor of protein synthesis active renin increased when extra sodium was delivered to the macula densa. 4. Salt intake changed the amount of renin present in the juxtaglomerular apparatus. In rats on a high salt intake the total renin was low and was all in an active form.
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Gillies et al. (1980) studied this question.
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