Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 2003Journal of Hypertension

Reduced activity of the kallikrein–kinin system predominates over renin–angiotensin system overactivity in all conditions of sodium balance in essential hypertensives and family-related hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do different sodium loads and enalapril administration alter the renin-angiotensin-aldosterone and kallikrein-kinin systems in essential hypertensives and offspring of hypertensive parents?

Population

105 subjects including 45 essential hypertensives, 30 offspring of hypertensive parents, and 30 normotensive…

Comparison

Three different sodium loads. Essential… vs Normotensive controls undergoing the same sodium…

Design

Cohort

Follow-up

3 days for enalapril administration

Authors

RSRamiro SánchezPreventive CardiologyHNH NollyUniversity of MendozaCGCarlos GiannoneAcademia Nacional de Medicina

Discussion

Loading...

Member takes

Overview

Lower urinary kallikrein activity may mark early renal impairment in hypertension families; leaves open whether kinin-system modulation improves outcomes.

Structured PICO

Do different sodium loads and enalapril administration alter the renin-angiotensin-aldosterone and kallikrein-kinin systems in essential hypertensives and offspring of hypertensive parents?

P
Population
105 subjects including 45 essential hypertensives (mean age 35 +/- 4 years, 25 males), 30 offspring of hypertensive parents (mean age 26 +/- 8 years, 16 males), and 30 normotensive controls (mean age 28 +/- 5 years, 20 males).
I
Intervention
Three different sodium loads (high, 250 mmol/l; normal, 140 mmol/l; and low, 20 mmol/l). Essential hypertensives additionally received enalapril 20 mg for 3 days.
C
Comparator
Normotensive controls undergoing the same sodium loads.
O
Outcome
Blood pressure, plasma renin activity, serum aldosterone, total kallikrein, urinary kallikrein-like activity, effective renal plasma flow, and glomerular filtration ratesurrogate

A hormonal imbalance between the renin-angiotensin-aldosterone and kallikrein-kinin systems exists in essential hypertensives and their offspring, which may impair renal circulation and sodium homeostasis.

Cite This Study

Sánchez et al. (2003) studied this question.

synapsesocial.com/papers/6a71368bf44fa9f079defd8dhttps://doi.org/10.1097/00004872-200302000-00034
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A gene for high urinary kallikrein may protect against hypertension in Utah kindreds.1989 · 163 citations
  2. 2Angiotensin II–Induced Hypertension in Bradykinin B 2 Receptor Knockout Mice2001 · 68 citations
  3. 3Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction.1991 · 100 citations
  4. 4Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension2002 · 30 citations
  5. 5Enhanced antinatriuresis in response to angiotensin II in essential hypertension2000 · 9 citations