What question did this study set out to answer?

To evaluate the effect of atrioventricular (AV) synchronous versus asynchronous pacing on plasma atrial natriuretic peptide (ANP) levels at rest and during exercise in patients with complete AV block.

August 1, 1988Pacing and Clinical Electrophysiology

Influence of AV Synchrony on the Plasma Levels of Atrial Natriuretic Peptide (ANP) in Patients with Total AV Block

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Why the study?

Does AV synchronous pacing (DDD) compared to asynchronous pacing (VVI) reduce plasma ANP levels in patients with total AV block?

Population

13 patients with DDD pacemakers due to total AV block

Comparison

DDD pacing at rest and during bicycle ergometry vs VVI pacing at rest and during bicycle ergometry

Design

Cross-sectional

Authors

KSKarl StanglInterventional Cardiology JWJ. WeilUniversity of Memphis KSKlaus SeitzUniversity for Peace

Discussion

Member takes

Implication

May favor DDD over VVI to limit ANP elevation in AV block; leaves open effects on symptoms or outcomes.

Key Points

To evaluate the effect of atrioventricular (AV) synchronous versus asynchronous pacing on plasma atrial natriuretic peptide (ANP) levels at rest and during exercise in patients with complete AV block.
Evaluated 13 patients with total AV block implanted with DDD pacemakers.
Measured plasma ANP levels at rest and during bicycle ergometry under both DDD and VVI pacing modes fixed at 70 beats/min.
Under DDD pacing, mean ANP was 36 ± 18 pg/mL at rest and increased 3.5-fold to 127 pg/mL during exercise (p < 0.01).
Switching to VVI pacing increased ANP to 73 ± 28 pg/mL at rest (203% of DDD resting level; p < 0.01) and to 216 ± 184 pg/mL during exercise (170% of DDD peak level; p < 0.01).

Structured PICO

Does AV synchronous pacing (DDD) compared to asynchronous pacing (VVI) reduce plasma ANP levels in patients with total AV block?

Population

13 patients with DDD pacemakers due to total AV block

Intervention

DDD pacing (AV synchronous pacing) at rest and during bicycle ergometry

Comparator

VVI pacing (70/min) at rest and during bicycle ergometry

Outcome

Plasma levels of Atrial Natriuretic Peptide (ANP)surrogate

AV synchronous pacing (DDD) maintains lower plasma ANP levels compared to asynchronous VVI pacing in patients with total AV block, likely due to reduced atrial wall tension.

Cite This Study

Stangl et al. (1988) studied this question.

synapsesocial.com/papers/6a7137ee35aa2c282ce286de https://doi.org/10.1111/j.1540-8159.1988.tb03969.x

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Influence of AV Synchrony on the Plasma Levels of Atrial Natriuretic Peptide (ANP) in Patients with Total AV Block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Influence of AV Synchrony on the Plasma Levels of Atrial Natriuretic Peptide (ANP) in Patients with Total AV Block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider