What question did this study set out to answer?

To establish an etiology- and phenotype-guided framework for disseminated intravascular coagulation, conceptualizing it as the final stage of failure in the coagulation system rather than a uniform disease entity.

January 1, 2026Juntendō Igaku/Juntendo igakuOpen Access

Revisiting the Concept of DIC: A Phenotype-guided Framework for Modern Hemostatic Medicine

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Authors

TCTomaz CrochemoreSociety of Critical Care Medicine ESECATERINA SCARLATESCUCarol Davila University of Medicine and Pharmacy

Discussion

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Implication

Review reveals distinct coagulopathy trajectories in critically ill patients, suggesting that phenotype-guided interventions replace uniform management of disseminated intravascular coagulation.

Key Points

To establish an etiology- and phenotype-guided framework for disseminated intravascular coagulation, conceptualizing it as the final stage of failure in the coagulation system rather than a uniform disease entity.
Synthesized pathophysiological evidence across specific coagulopathy etiologies, including sepsis, trauma, burns, malignancy, and obstetric complications.
Evaluated the utility of viscoelastic testing alongside specialized biomarkers (such as D-dimer, fibrinogen, protein C, antithrombin, and PAI-1) to identify evolving patient phenotypes.
Characterized disseminated intravascular coagulation as dynamic hemostatic system failure transitioning from hypercoagulability and microvascular fibrinolytic shutdown to consumptive hypocoagulation and hyperfibrinolysis.
Identified distinct clinical trajectories—including sepsis-induced, trauma-induced, and obstetric-associated coagulopathies—that require tailored management.
Demonstrated that phenotype-targeted strategies enable precision interventions, guiding anticoagulant administration during thrombotic phases and hemostatic resuscitation during bleeding phases.

Cite This Study

Crochemore et al. (2026) studied this question.

synapsesocial.com/papers/6a71384afebe604dd709ebcc https://doi.org/10.14789/ejmj.jmj25-0066-r

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Implication

Review reveals distinct coagulopathy trajectories in critically ill patients, suggesting that phenotype-guided interventions replace uniform management of disseminated intravascular coagulation.

Revisiting the Concept of DIC: A Phenotype-guided Framework for Modern Hemostatic Medicine

Discussion

Member takes

Implication

Key Points

Cite This Study

Revisiting the Concept of DIC: A Phenotype-guided Framework for Modern Hemostatic Medicine

Discussion

Member takes

Implication

Key Points

Cite This Study

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