Population
Rabbit isolated ventricular muscle (VM) and Purkinje fibers (PF)
Comparison
Lidocaine or nisoldipine added to almokalant vs Almokalant alone or time controls
Design
Preclinical
Authors
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Should not yet change clinical practice; hypothesis-generating for distinct mechanisms suppressing drug-induced EADs in vitro.
In vitro, lidocaine and nisoldipine attenuate almokalant-induced proarrhythmic markers (dispersion of repolarization and EADs) through different mechanisms.
Abrahamsson et al. (1996) studied this question.
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