Rate-Dependent Effects of the Class III Antiarrhythmic Drug Almokalant on Refractoriness in the Pig

7 isoflurane-anesthetized pigs

Intravenous almokalant (low dose: bolus 0.05 mumol/kg/min for 5 min followed by continuous infusion 0.0025 mumol/kg/min for 40 min; high dose: 0.2 mumol/kg/min for 5 min followed by 0.01 mumol/kg/min for 40 min)

Baseline (pre-drug administration)

Electrophysiologic parameters including PR, QRS, AH, HV, QT intervals, atrial effective refractory period (AERP), and ventricular effective refractory period (VERP)surrogate