Assessment of Left Ventricular Myocardial Performance by Tissue Doppler Echocardiography in Patients with Polycythemia Vera

AIMS: The aim of this study was to evaluate myocardial performance index (MPI) which reflects the combined systolic and diastolic performance of the ventricles by tissue Doppler imaging (TDI) in patients with polycythemia vera (PV). METHOD AND MATERIALS: Twenty-eight patients with PV (17 men; mean age 60±9 years) and 30 age-matched healthy subjects were prospectively evaluated. The diagnosis of PV was performed according to the World Health Organization (WHO) criteria. Left ventricular (LV) systolic and diastolic functions were assessed by conventional echocardiography and TDI. MPI of both the LV and right ventricles (RV) were measured by TDI method. RESULTS: The LV MPI was significantly higher in PV group than in the controls (0.61±0.16 vs. 0.49±0.05; P=0.001). Also, the RV MPI was impaired in patients with PV compared to the control subjects (0.51±0.11 vs. 0.43±0.09; P=0.005). RV late A filling velocity (Am) and RV isovolumetric relaxation time were significantly higher in the PV group compared to healthy subjects (P=0.03 and 0.05, respectively). In logistic regression models, PV was determined as an independent predictor of impaired MPI (odds ratio: 3.7; CI 95%, 1.2-7.5). In addition, pulmonary arterial pressure was significantly elevated in patients with PV compared to the controls (P=0.02). CONCLUSION: This study demonstrated that biventricular MPI is impaired in patients with PV.