Why the study?
Does bedtime administration of doxazosin 2 mg lower morning home blood pressure in patients with uncontrolled morning home hypertension?
Does bedtime administration of doxazosin 2 mg lower morning home blood pressure in patients with uncontrolled morning home hypertension?
Bedtime administration of doxazosin 2 mg effectively lowers morning home blood pressure in patients with uncontrolled morning hypertension.
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Bedtime doxazosin was associated with lower morning HBP; hypothesis-generating in this cohort and requires RCT confirmation before practice change.
The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)/morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.
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Gonokami et al. (2010) studied this question.
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