January 1, 1985The Journal of Biochemistry

Photosensitized Direct Cross-Linking of Fluorescent Analogs of ATP to the Adenine Recognition Domain in Myosin ATPase

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Population

Myosin subfragment-1 (S-1) ATPase

Comparison

Photosensitized direct cross-linking of… vs Addition of ATP or ADP

Design

Preclinical

Authors

THToshiaki HiratsukaAsahikawa Medical College Hospital

Discussion

Member takes

Implication

No immediate clinical implications; extends domain mapping of myosin ATPase in preclinical models.

Structured PICO

Population

Myosin subfragment-1 (S-1) ATPase

Intervention

Photosensitized direct cross-linking of ribose-modified fluorescent analogs of ATP (3'-O-anthraniloyl and 3'-O-(N-methylanthraniloyl) derivatives) by irradiation with visible light in the presence of FMN

Comparator

Addition of ATP or ADP (inhibition of cross-linking)

Outcome

Location of the adenine recognition site on myosin ATPase fragments after tryptic digestionsurrogate

Basic science findings suggest that the adenine recognition site of myosin ATPase is located predominantly on the 50K domain.

Cite This Study

Toshiaki Hiratsuka (1985) studied this question.

synapsesocial.com/papers/6a71429735aa2c282ce29244 https://doi.org/10.1093/oxfordjournals.jbchem.a135069

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Photosensitized Direct Cross-Linking of Fluorescent Analogs of ATP to the Adenine Recognition Domain in Myosin ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Photosensitized Direct Cross-Linking of Fluorescent Analogs of ATP to the Adenine Recognition Domain in Myosin ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider