February 14, 1995Biochemistry

Photoaffinity ADP analogs as covalently attached reporter groups of the active site of myosin subfragment 1

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Population

Rabbit skeletal myosin subfragment 1 (S1)

Design

Preclinical

Authors

YLYin LuoFudan University DWDonald WangWashington State University CCChristine CremoUniversity of Nevada, Reno

Discussion

Member takes

Implication

May guide myosin-targeted drug design; leaves open translation from skeletal models to cardiac disease.

Structured PICO

Population

Rabbit skeletal myosin subfragment 1 (S1)

Intervention

Photoaffinity labeling the active site with two ADP analogs (NANDP and Bz2 epsilon ADP) after trapping with vanadate

Outcome

Enzymatic properties and MgATPase activities

Photoaffinity labeling of skeletal myosin subfragment 1 reveals that actin binding affects the gamma-phosphate binding site rather than the adenine ring binding site.

Cite This Study

Luo et al. (1995) studied this question.

synapsesocial.com/papers/6a800ffc826e8e37b93d4070 https://doi.org/10.1021/bi00006a019

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Photoaffinity ADP analogs as covalently attached reporter groups of the active site of myosin subfragment 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Photoaffinity ADP analogs as covalently attached reporter groups of the active site of myosin subfragment 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider