January 1, 1984The Journal of Biochemistry

Distinct Structures of ATP and GTP Complexes in the Myosin ATPase

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Population

Myosin subfragment-1 ATPase (in vitro model)

Comparison

Affinity labeling with ribose-modified… vs Comparison between different nucleoside…

Design

Preclinical

Authors

THToshiaki HiratsukaAsahikawa Medical College Hospital

Discussion

Member takes

Implication

Informs myosin nucleotide-binding mechanisms in contraction research; leaves open extension to human cardiac isoforms.

Structured PICO

Population

Myosin subfragment-1 ATPase (in vitro model)

Intervention

Affinity labeling with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate

Comparator

Comparison between different nucleoside diphosphate analogs

Outcome

Fluorescent properties (hydrophobicity of environment and degree of burial in the protein)surrogate

Deep burial of ATP into the myosin active site appears essential for muscle contraction based on fluorescence studies of myosin-nucleoside diphosphate-vanadate complexes.

Cite This Study

Toshiaki Hiratsuka (1984) studied this question.

synapsesocial.com/papers/6a7142cf5d37378ac1de6a64 https://doi.org/10.1093/oxfordjournals.jbchem.a134807

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Distinct Structures of ATP and GTP Complexes in the Myosin ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Distinct Structures of ATP and GTP Complexes in the Myosin ATPase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider