Population
Spin-labeled muscle proteins (myosin and subfragment-1)
Design
Preclinical
Authors
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No immediate clinical implications for muscle disorders; leaves open extension to in vivo cardiac or skeletal mechanics.
Saturation transfer EPR spectroscopy reveals that the S-1 region of myosin has considerable mobility in intact myosin but is strongly immobilized upon binding to F-actin, providing insights into the molecular mechanism of muscle contraction.
Thomas et al. (1975) studied this question.
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