Population
Isolated subfragment No. 1 region of myosin, myosin monomers, and myosin filaments, with and without F-actin
Design
Preclinical
Authors
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Supports actomyosin models of contraction; leaves open validation in intact physiological systems.
Saturation transfer EPR spectroscopy demonstrates that the S1 region of myosin is flexible and becomes rigidly immobilized upon binding to F-actin, supporting current models of muscle contraction.
Thomas et al. (1975) studied this question.
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