Key result
Bovine cardiac myosin exhibits considerable segmental flexibility similar to skeletal myosin, but shows reduced conformational changes accompanying MgADP binding and MgATP hydrolysis.
Population
Bovine cardiac myosin and rabbit skeletal myosin
Comparison
Labeling with a fluorophore and a spin label… vs Rabbit skeletal myosin
Design
Preclinical
Authors
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Preclinical bovine myosin data leave open the basis for cardiac-skeletal contractile differences; human mechanistic studies required.
Cardiac myosin exhibits segmental flexibility similar to skeletal myosin, but its lower catalytic activity is associated with more restricted conformational changes during ATP hydrolysis.
Stone et al. (1981) studied this question. 1,5-IAEDANS and spin label vs. Rabbit skeletal myosin was evaluated on Local conformation and S1 flexibility. Bovine cardiac myosin exhibits considerable segmental flexibility similar to skeletal myosin, but shows reduced conformational changes accompanying MgADP binding and MgATP hydrolysis.
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