Modification of the Rapidly Reacting Thiols of Atrial and Ventricular Myosins

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Structured PICO

Population

Atrial and ventricular myosins

Intervention

Modification of SH-1 or SH-1 + SH-2 thiols with N-ethylmaleimide and spin labeling

Comparator

Ventricular versus atrial myosin

Outcome

Environmental variances around the rapidly reacting SH-1 thiol and generation of tension in synthetic actomyosin threadssurrogate

Demonstrates structural and functional disparities surrounding the SH-1 and SH-2 thiols between atrial and ventricular myosin isozymes.

Authors

No takes yet. Share an insight, caveat, or question.

Hypothesis-generating for atrial-ventricular myosin differences; should not yet inform clinical myosin-targeted therapies.

Srivastava et al. (1982) studied this question.

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