A Comparative Study of Reactive ‐ SH Groups of Cardiac and Skeletal Muscle Myosins

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Population

Cardiac and skeletal muscle myosins

Comparison

N-ethylmaleimide treatment in presence or… vs Comparison between cardiac and skeletal muscle…

Design

Preclinical

Authors

Discussion

Distinguishes cardiac from skeletal myosin biochemically; leaves open functional relevance to human cardiac disease or therapy.

Population

Cardiac and skeletal muscle myosins

Intervention

N-ethylmaleimide treatment in presence or absence of Mg-ADP

Comparator

Comparison between cardiac and skeletal muscle myosins

Outcome

Variations of Ca2+ and K+-ATPase activities and incorporation of N-[14C]ethylmaleimide into the whole myosin molecule and separated subunitssurrogate

Basic science study demonstrating biochemical differences in reactive thiol groups between cardiac and skeletal muscle myosins.

Klotz et al. (1976) studied this question.

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