Why the study?
Do thyroid hormones improve left ventricular function and myocyte remodeling in rats with spontaneously hypertensive heart failure?
Population
Rats with spontaneously hypertensive heart failure (SHHF) aged 20-21 months
Comparison
Thyroid hormones at three different doses… vs Untreated SHHF rats and age-matched Wistar-Furth…
Design
Preclinical
Follow-up
1 month (from 20 to 21 months of age)
Authors
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Suggests a potential therapeutic pathway for hypertensive heart failure; leaves open whether these structural benefits translate to human.
Do thyroid hormones improve left ventricular function and myocyte remodeling in rats with spontaneously hypertensive heart failure?
Thyroid hormone treatment in a rat model of hypertensive heart failure induces potentially beneficial changes in myocyte shape and reduces left ventricular wall stress.
Thomas et al. (2004) studied this question.
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