Key result
Alterations in hemodynamic load lead to diverse remodeling in the myocyte population, with smaller myocytes showing the highest growth potential and larger myocytes the highest potential to atrophy.
Population
Rat models of cardiac hypertrophy and cardiac atrophy
Design
Preclinical
Authors
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Regional myocyte size heterogeneity in rat hypertrophy models warrants caution in clinical extrapolation; leaves open human remodeling mechanisms.
Different alterations in hemodynamic load lead to diverse remodeling of the myocyte population, with smaller myocytes showing the highest growth potential and larger myocytes the highest potential to atrophy.
Campbell et al. (1991) studied Cardiac hypertrophy and atrophy. T3 treatment and heterotopic isotransplantation was evaluated on Regional changes in cellular dimensions (cell volume, length, cross-sectional area). Alterations in hemodynamic load lead to diverse remodeling in the myocyte population, with smaller myocytes showing the highest growth potential and larger myocytes the highest potential to atrophy.
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