Key result
Aortic banding induced greater myocyte hypertrophy in latitudinally oriented midwall fibers compared to longitudinal fibers, a regional difference not seen with isoproterenol infusion.
Population
Rat heart model
Comparison
Aortic banding and isoproterenol infusion vs Controls
Design
Preclinical
Follow-up
early and chronic stages
Authors
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Findings should not change clinical practice; leaves open fiber-specific remodeling in human pressure overload.
Aortic banding induces predominant hypertrophy in latitudinal fibers due to early diastolic axial stretching, a remodeling pattern distinct from that caused by isoproterenol infusion.
Kuribayashi et al. (1986) studied Myocyte hypertrophy. Aortic banding and isoproterenol infusion vs. Controls was evaluated on Cross-sectional area of muscle fibers and end-diastolic three-dimensional deformation. Aortic banding induced greater myocyte hypertrophy in latitudinally oriented midwall fibers compared to longitudinal fibers, a regional difference not seen with isoproterenol infusion.
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