What question did this study set out to answer?

To determine the effects of acute and long-standing hypocalcemia on blood pressure regulation and plasma renin activity across different postures.

May 1, 1974The Journal of Clinical Endocrinology & Metabolism

Effect of Acute and Long-standing Hypocalcemia on Blood Pressure and Plasma Renin Activity in Man

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To determine the effects of acute and long-standing hypocalcemia on blood pressure regulation and plasma renin activity across different postures.
Induced acute hypocalcemia using EDTA infusion in healthy volunteers and patients with mild renal failure, measuring outcomes in both supine and upright postures.
Evaluated supine and upright blood pressure and plasma renin activity in patients with chronic hypocalcemia secondary to idiopathic hypoparathyroidism or pseudohypoparathyroidism.
Acute hypocalcemia caused significant orthostatic hypotension that correlated directly with the magnitude of serum calcium reduction, while supine blood pressure remained unchanged.
Plasma renin activity in both supine and standing positions remained unaltered during acute hypocalcemia compared with normocalcemic controls.
Long-standing hypocalcemia was not accompanied by alterations in blood pressure or plasma renin activity.

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Implication

Clinical physiological study reveals orthostatic hypotension without altered renin activity during acute hypocalcemia in human subjects, suggesting renin secretion is calcium-independent.

Cite This Study

Llach et al. (1974) studied this question.

synapsesocial.com/papers/6a715202febe604dd70a0153 https://doi.org/10.1210/jcem-38-5-841

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Implication

Clinical physiological study reveals orthostatic hypotension without altered renin activity during acute hypocalcemia in human subjects, suggesting renin secretion is calcium-independent.

Effect of Acute and Long-standing Hypocalcemia on Blood Pressure and Plasma Renin Activity in Man

Key Points

Discussion

Implication

Cite This Study

Effect of Acute and Long-standing Hypocalcemia on Blood Pressure and Plasma Renin Activity in Man

Key Points

Discussion

Implication

Cite This Study