January 1, 1989American Journal of Hypertension
Reduction of Blood Pressure During Long-term Treatment With Active Vitamin D (Alphacalcidol) Is Dependent on Plasma Renin Activity and Calcium Status
Why the study?
Does alphacalcidol reduce blood pressure in subjects with mild to moderate essential hypertension?
Population
39 subjects with mild to moderate essential hypertension
Comparison
Alphacalcidol 1 microgram over four months vs Placebo
Design
RCT, double-blind
Follow-up
four months
Authors
Discussion
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Implication
Alphacalcidol does not lower mean blood pressure in essential hypertension; extends evidence for selective diastolic benefit in low baseline PRA.
Structured PICO
Does alphacalcidol reduce blood pressure in subjects with mild to moderate essential hypertension?
P
Population
39 subjects with mild to moderate essential hypertension
I
Intervention
Alphacalcidol (1 alpha-hydroxy-vitamin D3) 1 microgram over four months
C
Comparator
Placebo
O
Outcome
Blood pressure response and plasma renin activity (PRA)surrogate
Alphacalcidol supplementation increases plasma renin activity and may selectively reduce diastolic blood pressure in hypertensive patients with low baseline renin activity.
Cite This Study
Lind et al. (1989) studied this question.