Why the study?
Does cholecalciferol treatment improve endothelial function and downregulate the renin-angiotensin system in essential hypertensive patients with hypovitaminosis D?
Population
86 individuals total: 33 consecutive patients with essential hypertension and hypovitaminosis D, 33…
Comparison
Cholecalciferol 50,000 IU/week orally for 8 weeks vs Baseline values and untreated control groups
Design
Cohort
Follow-up
8 weeks
Authors
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May lower RAAS activity and improve vascular function in deficient hypertensives; leaves open clinical benefit pending randomized trials.
Does cholecalciferol treatment improve endothelial function and downregulate the renin-angiotensin system in essential hypertensive patients with hypovitaminosis D?
Vitamin D replacement in hypertensive patients with hypovitaminosis D downregulates the peripheral renin-angiotensin system and improves endothelial function.
Carrara et al. (2016) studied this question.
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