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January 2, 2013Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Cholecalciferol administration blunts the systemic renin–angiotensin system in essential hypertensives with hypovitaminosis D

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Why the study?

Does cholecalciferol reduce systemic RAS activity in drug-free patients with essential hypertension and hypovitaminosis D?

Population

15 consecutive drug-free patients with essential hypertension and hypovitaminosis D

Design

Cohort

Follow-up

two months

Authors

DCDavide CarraraMBM. BerniniABAlessandra Bacca

Discussion

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Overview

Supports vitamin D repletion to blunt RAS activity in deficient hypertensives; leaves open BP effects and needs randomized confirmation.

Structured PICO

Does cholecalciferol reduce systemic RAS activity in drug-free patients with essential hypertension and hypovitaminosis D?

P
Population
15 consecutive drug-free patients with essential hypertension and hypovitaminosis D
I
Intervention
Cholecalciferol 25000 I.U. oral once a week for two months, while maintaining a constant-salt diet
O
Outcome
Renin-angiotensin system (RAS) activity (plasma angiotensinogen, renin, PRA, angiotensin II, aldosterone and urinary angiotensinogen), blood pressure, and plasma vitamin D levels (25(OH)D)surrogate

Pharmacological correction of vitamin D levels with cholecalciferol blunts systemic RAS activity in essential hypertensives with hypovitaminosis D, though it did not lower blood pressure in this small study.

Cite This Study

Carrara et al. (2013) studied this question.

synapsesocial.com/papers/6a8942bdb11dee029fbd4cd3https://doi.org/10.1177/1470320312471149
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Also Consider

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  4. 4Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin–angiotensin–aldosterone system activity and the efficacy of renin–angiotensin–aldosterone system blockade in the kidney2011 · 93 citations
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