The Effect of High Dose Cholecalciferol on Arterial Stiffness and Peripheral and Central Blood Pressure in Healthy Humans: A Randomized Controlled Trial
View Full Paper
Ask AI
Bookmark
Share
Key result
Oral cholecalciferol fails to improve PWV or BP versus placebo in healthy normotensive adults.
- MD -0.2
- 95% CI -0.9 to 0.4
- n=40
Why the study?
Does oral cholecalciferol 3000 IU/day improve arterial stiffness and blood pressure in healthy normotensive adults?
Population
40 healthy normotensive adults
Comparison
Oral cholecalciferol 3000 IU/day for 16 weeks vs Matching placebo
Design
RCT, randomised, double-blinded
Follow-up
16 weeks
Authors
Discussion
Loading...
Member takes
Implication
Cholecalciferol 3000 IU/day yields no vascular or BP benefit in healthy normotensives; challenges observational links and proposed supplementation in this population.
Study Design
Type
RCT (n=40)
Blinding
Double-blind
Randomization
1:1
Multicenter
No
Structured PICO
Does oral cholecalciferol 3000 IU/day improve arterial stiffness and blood pressure in healthy normotensive adults?
P
Population
40 healthy normotensive adults with baseline serum 25-OH vitamin D ≤50 nmol/L, free of medications affecting vascular parameters, followed for 16 weeks.
I
Intervention
Oral cholecalciferol 3000 IU/day for 16 weeks
C
Comparator
Matching placebo
O
Outcome
Changes in pulse wave velocity (PWV), augmentation index (AIx), peripheral and central blood pressure, and 24-hour ambulatory blood pressure at 16 weekssurrogate
Main Result
Mean Difference: -0.2 (95% CI -0.9–0.4)
Absolute Event Rate: 0% vs -0.1%
High-dose oral cholecalciferol supplementation does not improve arterial stiffness or blood pressure in healthy normotensive adults.
Limitations
- Relatively small sample size
- Short follow-up time of 16 weeks
- Slight baseline differences between groups in age, BMI, and proportion of men
- Performed only during winter, limiting generalizability to other seasons or latitudes with greater sun exposure
- Changes in diet, sun exposure, or use of solarium were not recorded during the trial
Cite This Study
Bressendorff et al. (2016) conducted an RCT in Vitamin D deficiency in healthy normotensive adults (n=40). Cholecalciferol vs. Placebo was evaluated on Change in Pulse Wave Velocity (PWV) (MD -0.2, 95% CI -0.9 to 0.4). Oral cholecalciferol 3000 IU/day for 16 weeks did not significantly change pulse wave velocity (mean difference -0.2 m/s) or blood pressure compared to placebo in healthy normotensive adults.
View Full Paper
Ask AI
Bookmark
Share