Key result
A single high (300,000 IU) or low dose (75,000 IU) of vitamin D3 did not significantly reduce postprandial arterial stiffness or leukocyte activation in overweight, vitamin D-deficient women.
Why the study?
Does a single high dose of cholecalciferol improve postprandial arterial stiffness and inflammation compared to a low dose in healthy, premenopausal, overweight or obese, vitamin D-deficient women?
RCT (n=24)
Double-blind
1:1
No
Does a single high dose of cholecalciferol improve postprandial arterial stiffness and inflammation compared to a low dose in healthy, premenopausal, overweight or obese, vitamin D-deficient women?
A single high or low dose of vitamin D3 does not significantly improve postprandial arterial stiffness or leukocyte activation in overweight, vitamin D-deficient women.
No takes yet. Share an insight, caveat, or question.
No support for single-dose vitamin D3 to blunt postprandial stiffness or inflammation; challenges acute pleiotropic effects and warrants repeated-dosing trials.
Vries et al. (2016) conducted an RCT in Vitamin D deficiency (n=24). Cholecalciferol (vitamin D3) vs. 75,000 IU was evaluated on Postprandial leukocyte activation markers, pulse wave velocity (PWV), and augmentation index (AIx) during an oral fat loading test (AUC). A single high (300,000 IU) or low dose (75,000 IU) of vitamin D3 did not significantly reduce postprandial arterial stiffness or leukocyte activation in overweight, vitamin D-deficient women.
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