Why the study?
Does transitioning from clozapine to olanzapine improve pathologic cardiac parameters in a patient with schizophrenia?
Population
1 patient with long-standing schizophrenia treated with clozapine, presenting with prolonged QT interval and…
Comparison
Transition from clozapine to olanzapine vs Baseline (clozapine treatment)
Design
Case_report
Follow-up
2 years
Authors
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May normalize HRV after clozapine-to-olanzapine switch in schizophrenia; single case leaves open utility of power spectrum monitoring.
Does transitioning from clozapine to olanzapine improve pathologic cardiac parameters in a patient with schizophrenia?
Switching from clozapine to olanzapine reversed pathologic autonomic nervous system activity and improved heart rate, demonstrating the utility of power spectrum analysis of heart rate variability in monitoring antipsychotic cardiac side effects.
Cohen et al. (2001) studied this question.
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