January 1, 1999Journal of Hypertension
Double-blind, randomized, multicentre comparison of the effects of amlodipine and perindopril on 24 h therapeutic coverage and beyond in patients with mild to moderate hypertension
Why the study?
Does amlodipine improve 24-hour therapeutic coverage and residual blood pressure control after dose omission compared to perindopril in patients with mild to moderate hypertension?
Population
96 patients with mild to moderate hypertension (diastolic blood pressure ≥ 90 mmHg and ≤ 109 mmHg).
Comparison
Amlodipine 5-10 mg once a day for 60 days. vs Perindopril 4-8 mg once a day for 60 days.
Design
RCT, randomly allocated, double-blind
Follow-up
60 days
Authors
Discussion
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Implication
Comparable 24-hour coverage supports either agent for mild-moderate hypertension; confirms equivalent trough:peak ratios in this RCT.
Structured PICO
Does amlodipine improve 24-hour therapeutic coverage and residual blood pressure control after dose omission compared to perindopril in patients with mild to moderate hypertension?
P
Population
96 patients with mild to moderate hypertension (diastolic blood pressure ≥ 90 mmHg and ≤ 109 mmHg).
I
Intervention
Amlodipine 5-10 mg once a day for 60 days.
C
Comparator
Perindopril 4-8 mg once a day for 60 days.
O
Outcome
Trough:peak ratios calculated by global and individualized approaches from 24 h ambulatory blood pressure recordings.surrogate
Amlodipine and perindopril provide comparable 24-hour blood pressure coverage, but amlodipine maintains more effective blood pressure control after a missed dose.
Cite This Study
Zannad et al. (1999) studied this question.