Why the study?
To investigate the diastolic LV response to isometric handgrip exercise among healthy middle-aged men with high physical activity levels versus matched sedentary individuals.
Does a high physical activity level improve the diastolic left ventricular response to isometric handgrip exercise in healthy middle-aged men compared to sedentary individuals?
Population
Two groups of 10 healthy men aged 41-51 years
Comparison
High weekly physical activity (>3000 METs x min/week) vs low physical activity (<300 METs x min/week)
Design
Comparative physiological study
Authors
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May support activity to preserve diastolic response during stress; leaves open larger trials on HFpEF risk.
Does a high physical activity level improve the diastolic left ventricular response to isometric handgrip exercise in healthy middle-aged men compared to sedentary individuals?
High levels of physical activity in middle-aged men are associated with improved lusitropic cardiac function during isometric handgrip exercise compared to sedentary behavior.
Rovithis et al. (2022) studied this question.
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