Why the study?
Does altering coronary inflow and outflow pressures affect coronary vascular resistance in the isolated dog heart?
Does altering coronary inflow and outflow pressures affect coronary vascular resistance in the isolated dog heart?
Inflow and outflow pressures interact to determine the shape of the coronary pressure-flow relationship, suggesting that linear regression poorly estimates resistance and zero-flow pressure.
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Pressure-dependent resistance in isolated canine hearts cautions against linear regression for zero-flow estimates; leaves open translation to human coronary physiology.
Hanley et al. (1984) studied this question.
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