Why the study?
What is the optimal treatment strategy (thrombolysis vs surgical treatment) for prosthetic valve thrombosis?
What is the optimal treatment strategy (thrombolysis vs surgical treatment) for prosthetic valve thrombosis?
The optimal management of left-sided prosthetic valve thrombosis remains uncertain, requiring individualized decisions based on patient and clinical factors, highlighting the need for prospective randomized trials.
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Management of left-sided prosthetic valve thrombosis requires individualized decisions; leaves open optimal strategy without randomized trials.
Prosthetic valve thrombosis is a potentially life-threatening complication associated with high morbidity and mortality. Transthorasic and transoesophageal echocardiography play an important role to the diagnosis and provides incremental information about the optimal treatment strategy, while fluoroscopy and cardiac computed tomography may be of added value. Guidelines differ on whether surgical treatment or fibrinolysis should be the treatment of choice for the management of left-sided prosthetic valve thrombosis and these uncertainties underline the need for further prospective randomized controlled trials. Thrombus size, New York Heart Association functional class of the patient, the possible contraindications, the availability of each therapeutic option and the clinician's experience are important determinants for the management of prosthetic valve thrombosis.
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Bonou et al. (2012) studied this question.
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