Why the study?
Does the type of heart valve prosthesis (artificial vs biological) affect in vivo thrombin formation as measured by FpA levels in patients receiving oral anticoagulants?
Population
99 subjects: 38 patients receiving oral anticoagulants for artificial heart valve prostheses, 20 patients…
Comparison
Oral anticoagulants for artificial heart valve… vs Oral anticoagulants for biological heart valve…
Design
Cohort
Authors
Loading...
Artificial valves linked to higher thrombin formation than biological at target INR; hypothesis-generating for intensified anticoagulation, needs RCT confirmation.
Does the type of heart valve prosthesis (artificial vs biological) affect in vivo thrombin formation as measured by FpA levels in patients receiving oral anticoagulants?
Patients with artificial heart valves have higher in vivo thrombin formation (measured by FpA) than those with biological valves despite optimal oral anticoagulation, suggesting a need for higher intensity anticoagulation.
Pengo et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: