Why the study?
Does Ammonium 5-tungsto-2-antimoniate (HPA 23) protect against lethal encephalomyocarditis and vesicular stomatitis virus infections in mice?
Population
Mice infected with encephalomyocarditis virus or vesicular stomatitis virus
Comparison
Ammonium 5-tungsto-2-antimoniate administered as… vs Untreated mice
Design
Preclinical
Authors
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HPA 23 protects mice from EMC/VSV lethality without reducing titres; leaves open non-replication antiviral mechanisms for further study.
Does Ammonium 5-tungsto-2-antimoniate (HPA 23) protect against lethal encephalomyocarditis and vesicular stomatitis virus infections in mice?
HPA 23 demonstrates in vivo protective activity against lethal EMC and VSV infections in mice, suggesting death from EMC may not be solely related to virus multiplication.
Werner et al. (1976) studied this question.
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