Population
Mice 24 hours to 6 weeks old
Comparison
Coxsackie B1 virus infection vs Adult mice vs. suckling mice
Design
Preclinical
Authors
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Immature interferon production may explain poorer Coxsackie outcomes in suckling mice; leaves open relevance to human neonates.
The difference in outcome of Coxsackie B1 infection between suckling and older mice may be explained by the inability of immature cells to produce interferon.
Heineberg et al. (1964) studied this question.
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