Why the study?
Does acute mitral insufficiency of variable severity alter coronary blood flow and myocardial oxygen consumption in anesthetized dogs?
Does acute mitral insufficiency of variable severity alter coronary blood flow and myocardial oxygen consumption in anesthetized dogs?
Acute mitral insufficiency increases coronary blood flow and myocardial oxygen consumption, suggesting increased energy expenditure or decreased efficiency of the left ventricle.
Suggests increased LV energy expenditure in acute mitral insufficiency; hypothesis-generating in canine models and leaves open human relevance.
In anesthetized dog, acute mitral insufficiency of variable severity results in an increase in coronary blood flow and myocardial oxygen consumption. The increase in oxygen consumption is interpreted as meaning either that the left ventricle expends a significant amount of energy in regurgitating blood into the left atrium during mitral insufficiency, or that mitral insufficiency induces a decrease of the efficiency of the left ventricle or both.
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Wégria et al. (1958) studied this question.