Why the study?
Does infusion of ibuprofen or prostacyclin prevent platelet activation and thromboxane B2 release during coronary occlusion in a canine model?
Population
Conscious dogs with previously cannulated cardiac lymph vessels undergoing 10-60 minute coronary occlusions
Comparison
Infusion of ibuprofen or prostacyclin vs Untreated animals
Design
Preclinical
Follow-up
10-60 minutes of occlusion plus reperfusion
Authors
Loading...
These agents blunt ischemia-induced platelet changes in canines; leaves open translation to human coronary syndromes.
Does infusion of ibuprofen or prostacyclin prevent platelet activation and thromboxane B2 release during coronary occlusion in a canine model?
In a canine model of coronary occlusion, ibuprofen and prostacyclin prevented the ischemia-induced rise in thromboxane B2 and fall in platelet counts in cardiac lymph.
Michael et al. (1986) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: