June 3, 1997Circulation
Enhanced Expression of Hepatocyte Growth Factor/c-Met by Myocardial Ischemia and Reperfusion in a Rat Model
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Discussion
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Implication
Randomized trial evaluates HGF and c-Met regulation post-myocardial ischemia, indicating their role in heart repair.
Key Points
- The study aims to assess the regulation of hepatocyte growth factor (HGF) and its receptor, c-Met, in the context of myocardial ischemia and reperfusion.
- Plasma concentration of HGF was monitored post-reperfusion in a rat model of myocardial ischemia.
- Northern blotting assessed HGF and c-Met mRNA expression in myocardial tissue over time.
- Immunohistochemical studies identified cellular expression of HGF and c-Met in the heart and other organs.
- HGF plasma levels increased within 1 hour of reperfusion, peaking at 3 hours.
- HGF mRNA expression was augmented threefold at 24 and 48 hours, remaining elevated by twofold at 120 hours post-reperfusion.
- c-Met mRNA expression in the heart was upregulated in parallel with HGF but not in other examined organs.
Cite This Study
Ono et al. (1997) studied this question.