Why the study?
Does prorenin blockade with PRAM-1 improve cardiovascular and renal damage in spontaneously hypertensive rats?
Population
20-wk-old male spontaneously hypertensive rats receiving a normal diet and 8-wk-old male SHRs given food…
Comparison
Prorenin inhibitor (PRAM-1, 0.1 mg.kg.day) via… vs Control (no PRAM-1)
Design
Preclinical
Follow-up
8 weeks (for salt-loaded rats)
Authors
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Hypothesis-generating for prorenin blockade in salt-sensitive hypertension; requires human trials before clinical consideration.
Does prorenin blockade with PRAM-1 improve cardiovascular and renal damage in spontaneously hypertensive rats?
Blockade of nonproteolytic activation of prorenin provides significant cardiovascular and renal benefits in a rat model of accelerated hypertension, independent of blood pressure lowering.
Sušić et al. (2008) studied this question.
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