Why the study?
Does eplerenone improve renal injury and modulate the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats?
Population
Dahl salt-sensitive rats and Dahl salt-resistant rats fed high-salt or low-salt diets
Comparison
Eplerenone 100 mg/kg per day orally for 8 weeks vs No eplerenone treatment
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports preclinical rationale for eplerenone in salt-sensitive hypertension; leaves open translation to clinical practice.
Does eplerenone improve renal injury and modulate the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats?
Mineralocorticoid receptor blockade with eplerenone attenuates renal injury and decreases tissue renin-angiotensin system activity in a rat model of salt-sensitive hypertension.
Zhu et al. (2009) studied this question.
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