Which factor mediates reno-renal control of renin gene expression?
Population
Adult male Sprague-Dawley rats in a two-kidney, one-clip model with various unilateral reductions of renal…
Comparison
Unilateral renal denervation and/or treatment… vs Control rats without denervation or losartan…
Design
Preclinical
Follow-up
10 days
Authors
Discussion
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Member takes
Implication
Animal data do not implicate nerves or AT1 signaling; hypothesis-generating for humoral mediators, precluding clinical translation.
Structured PICO
P
Population
Adult male Sprague-Dawley rats in a two-kidney, one-clip model with various unilateral reductions of renal blood flow (silver clips of 0.2, 0.3, and 0.4 mm inner diameter)
I
Intervention
Unilateral renal denervation and/or treatment with losartan (angiotensin II antagonist)
C
Comparator
Control rats without denervation or losartan treatment
O
Outcome
Renal renin messenger RNA levelssurrogate
The suppression of renin gene expression in the contralateral kidney of a stenosed kidney is likely mediated by an unidentified humoral factor rather than systemic blood pressure, AT1 receptors, or renal nerves.
Cite This Study
Holmer et al. (1993) studied this question.