This report highlights the teratogenic effects of warfarin, known as congenital warfarin syndrome, which includes nasal hypoplasia and bone stippling.
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Supports caution with warfarin in pregnancy; leaves open need for prospective data on embryopathy risks.
A rare congenital nasal deformity due to warfarin embryopathy is reported. The commonest anomalies described in this syndrome are: hypoplasia of the nose, stippling of bone, optic atrophy and mental retardation. The various abnormalities and the mechanism of warfarin teratogenesis are discussed.
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M. S. Zakzouk (1986) studied this question.
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