Why the study?
Does maternal ingestion of warfarin during pregnancy cause congenital abnormalities in the baby?
Does maternal ingestion of warfarin during pregnancy cause congenital abnormalities in the baby?
Maternal ingestion of warfarin during pregnancy can cause congenital warfarin syndrome, characterized by skeletal and ocular abnormalities.
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Case report of fetal warfarin syndrome supports known teratogenicity; leaves open incidence estimates and optimal alternatives in pregnancy.
A case is reported of a baby born with congenital abnormalities due to maternal ingestion of warfarin during pregnancy. Warfarin is known to be teratogenic, producing characteristic abnormalities, namely a hypoplastic nose, stippled epiphyses, and skeletal abnormalities. A variety of ocular abnormalities have been reported. Ophthalmologists should seek a history of maternal warfarin ingestion when seeing a baby with congenital ocular abnormalities. They should also be aware of the possible teratogenic effects when considering warfarin therapy for a woman of childbearing age.
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Baillie et al. (1980) studied this question.
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