Key result
Maternal warfarin exposure linked to fetal warfarin syndrome presenting with truncus arteriosus.
Case Report (n=1)
This case report highlights the severe teratogenic effects of maternal warfarin use during pregnancy, resulting in Fetal Warfarin Syndrome with truncus arteriosus and nasal hypoplasia.
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Reinforces caution with warfarin in pregnancy; single case leaves open full spectrum of associated cardiac defects.
A two-month-old male infant presented with history of respiratory difficulty and got admitted with provisional diagnosis of pneumonia. On examination patient was having unilateral nasal hypoplasia and cyanosis with echocardiography showing truncus arteriosus. Detail history revealed that mother had valve replacement and she was taking warfarin during pregnancy. After initial management patient was referred to pediatric cardiac surgery and plastic surgery for further management. Parents were counseled regarding contraception and family planning.
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Shah et al. (2022) conducted a case report in Fetal Warfarin Syndrome (n=1). Maternal warfarin exposure was evaluated. Maternal warfarin exposure during pregnancy resulted in fetal warfarin syndrome in a male infant, characterized by unilateral nasal hypoplasia, cyanosis, and truncus arteriosus.
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