Why the study?
Is maternal warfarin intake at doses <5 mg/day safe from causing fetal warfarin syndrome in pregnant women with rheumatic heart disease?
Population
4 neonates born to mothers with rheumatic heart disease
Design
Case_series
Authors
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Low-dose warfarin may cause fetal warfarin syndrome; case reports leave open dose-safety thresholds in rheumatic heart disease.
Is maternal warfarin intake at doses <5 mg/day safe from causing fetal warfarin syndrome in pregnant women with rheumatic heart disease?
Maternal warfarin intake at doses <5 mg/day can still result in fetal warfarin syndrome, challenging the consensus that this low dose is universally safe during pregnancy.
Basu et al. (2015) studied this question.
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