Key result
Maternal exposure to low-dose warfarin (5 mg/day) resulted in a newborn presenting with skeletal abnormalities and a ventricular septal defect consistent with warfarin embryopathy.
Why the study?
Does low-dose maternal warfarin (≤5 mg/day) prevent fetal warfarin syndrome in pregnant patients with mechanical heart valves?
Population
1 newborn born to a mother anticoagulated with warfarin due to mechanical mitral and aortic heart valves
Design
Case_report
Follow-up
1 year
Authors
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Low-dose warfarin may still cause embryopathy; this case report leaves open fetal safety at ≤5 mg/day in mechanical valve pregnancies.
Case Report (n=1)
Does low-dose maternal warfarin (≤5 mg/day) prevent fetal warfarin syndrome in pregnant patients with mechanical heart valves?
Low-dose warfarin (≤5 mg/day) during pregnancy may still carry a risk of warfarin embryopathy, challenging the assumption that low doses are entirely safe for the fetus.
Sousa et al. (2018) conducted a case report in Fetal warfarin syndrome (n=1). Low-dose warfarin was evaluated on Fetal warfarin syndrome (skeletal abnormalities and ventricular septal defect). Maternal exposure to low-dose warfarin (5 mg/day) resulted in a newborn presenting with skeletal abnormalities and a ventricular septal defect consistent with warfarin embryopathy.
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