Why the study?
The role of epoxyeicosatrienoic acids, nitric oxide/reactive oxygen species balance, and endothelin-1 in conduit artery endothelial dysfunction during essential hypertension was unclear.
Do epoxyeicosatrienoic acids, nitric oxide, and endothelin-1 pathways contribute to conduit artery endothelial dysfunction in essential hypertension?
Population
28 untreated patients with essential hypertension and 30 normotensive control subjects
Comparison
Brachial infusion of fluconazole and L-NMMA during hand skin heating-induced flow-mediated dilatation vs controls
Design
Cross-sectional functional and biological study
Authors
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Impaired EET and NO contributions may underlie hypertensive endothelial dysfunction; leaves open therapeutic relevance pending interventional studies.
Do epoxyeicosatrienoic acids, nitric oxide, and endothelin-1 pathways contribute to conduit artery endothelial dysfunction in essential hypertension?
Essential hypertension is associated with conduit artery endothelial dysfunction driven by an impaired contribution of epoxyeicosatrienoic acids, altered NO/ROS balance, and endothelin-1 pathways.
Bellien et al. (2012) studied this question.
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