Ca²⁺-Activated Cl⁻Current in Retinal Arteriolar Smooth Muscle

View Full Paper

Ask AI

Bookmark

Population

Retinal arteriolar myocytes within intact isolated arteriolar segments

Comparison

Electrophysiological characterization and… vs Control conditions

Design

Preclinical

Authors

Discussion

Ca2+-activated Cl- currents contribute to retinal vasoconstriction; leaves open whether blockade affects perfusion or disease in vivo.

Population

Retinal arteriolar myocytes within intact isolated arteriolar segments

Intervention

Electrophysiological characterization and pharmacological blockade (9-AC, SITS, DIDS, nimodipine, caffeine)

Comparator

Control conditions (normal bathing medium, basal vascular tone)

Outcome

Biophysical, pharmacologic, and functional properties of the Ca2+-activated Cl- currentsurrogate

Retinal arteriolar myocytes possess a Ca2+-activated Cl- current that contributes to agonist-induced retinal vasoconstriction.

McGahon et al. (2009) studied this question.

View Full Paper

Ask AI

Bookmark