April 1, 1993Journal of Cardiovascular Pharmacology

Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157

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Population

Isolated heart mitochondria, isolated neonatal ventricular myocytes, isolated cardiac sarcolemmal vesicles…

Comparison

CGP-37157 (benzothiazepine compound) vs null

Design

Preclinical

Authors

DCDavid A. CoxInterventional Cardiology LCLaura ConfortiBabraham Institute NSNicholas SperelakisIllinois College

Discussion

Member takes

Implication

May serve as selective mitochondrial NCX tool in cardiac models; clinical translation remains untested.

Structured PICO

Population

Isolated heart mitochondria, isolated neonatal ventricular myocytes, isolated cardiac sarcolemmal vesicles, and isolated cardiac sarcoplasmic reticulum vesicles

Intervention

CGP-37157 (benzothiazepine compound)

Comparator

null

Outcome

Inhibition of mitochondrial Na(+)-Ca2+ exchange activity and effects on L-type voltage-dependent calcium channel, sarcolemmal Na(+)-Ca2+ exchanger, Na(+)-K(+)-ATPase, and sarcoplasmic reticulum Ca(2+)-ATPasesurrogate

CGP-37157 is a potent, selective, and specific inhibitor of mitochondrial Na(+)-Ca2+ exchange at concentrations <= 10 microM, without affecting other major cardiac calcium and sodium transport mechanisms.

Cite This Study

Cox et al. (1993) studied this question.

synapsesocial.com/papers/6a71a2fb5d37378ac1debc7d https://doi.org/10.1097/00005344-199304000-00013

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Bookmark

Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider